238100

CRM1 Inhibitor III

The CRM1 Inhibitor III controls the biological activity of CRM1. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinonimo/i: CRM1 Inhibitor III, (Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 ProteinInhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
• Formula empirica (notazione di Hill): C₁₆H₁₂BrClN₂O₂
• Numero CAS: 1178871-47-0
• Peso molecolare: 379.64
• Numero MDL: MFCD32671850
• Codice UNSPSC: 12352200
• NACRES: NA.28

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: powder
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 100 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(NC1=CC=CC(Cl)=C1)/C=C\C(NC2=CC=C(Br)C=C2)=O

Descrizione

Descrizione generale

A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC₅₀ = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC₅₀ = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Monovich, L., et al. 2009. Biochim Biophys Acta.1789, 422.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable