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C0868

Chromeceptin

Name: Chromeceptin
Brand: SIGMA

≥98% (HPLC), solid

Sinonimo/i:

2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene, 94G6

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About This Item

Formula empirica (notazione di Hill):

C₁₉H₁₆F₃N₃O

Numero CAS:

331859-86-0

Peso molecolare:

359.35

Numero MDL:

MFCD00815850

Codice UNSPSC:

51111800

ID PubChem:

24724431

NACRES:

NA.77

Prodotti consigliati

Slide 1 of 1

1 of 1

USP

1683504

Trientine hydrochloride

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

yellow to brown

Solubilità

H₂O: <2 mg/mL
DMSO: >20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

CN(C)c1ccc2C(c3cccc(c3)C(F)(F)F)C(C#N)=C(N)Oc2c1

InChI

1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3
GVINXTXGDDSXFQ-UHFFFAOYSA-N

Azioni biochim/fisiol

Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Caratteristiche e vantaggi

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2.

Yongmun Choi et al.

Chemistry & biology, 13(3), 241-249 (2006-04-28)

Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecular pathways that modulate IGF2 signaling, by using chromeceptin, a synthetic

Identification of bioactive molecules by adipogenesis profiling of organic compounds.

Yongmun Choi et al.

The Journal of biological chemistry, 278(9), 7320-7324 (2002-12-24)

An important step in the postgenomic drug discovery is the construction of high quality chemical libraries that generate bioactive molecules at high rates. Here we report a cell-based approach to composing a focused library of biologically active compounds. A collection

Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma.

Hyang Sook Seol et al.

Scientific reports, 10(1), 21412-21412 (2020-12-10)

Stemness factors control microRNA expression in cancer stem cells. Downregulation of miR-100 and miR-125b is associated with tumor progression and prognosis of various cancers. Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b

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