203389
Blebbistatin, Racemic
≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®
Sinonimo/i:
InSolutionBlebbistatin, Racemic
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About This Item
Formula empirica (notazione di Hill):
C18H16N2O2
Peso molecolare:
292.33
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
product name
Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II
Livello qualitativo
Saggio
≥97% (HPLC)
Forma fisica
liquid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
desiccated (hygroscopic)
protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Descrizione generale
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
Azioni biochim/fisiol
Cell permeable: yes
Primary Target
ATPase
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Stato fisico
A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Ricostituzione
Following initial thaw, aliquot and freeze (-20°C).
Altre note
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto d’infiammabilità (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificati d'analisi (COA)
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