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Key Documents

1.51463

Supelco

Chromolith® RP-18 endcapped (monolithic) HPLC Columns

L × I.D. 25 mm x 4.6 mm HPLC Column

Sinonimo/i:

Chromolith® Flash RP-18 endcapped 25-4.6 HPLC column

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About This Item

Codice UNSPSC:
41115700
NACRES:
SB.52

product name

Chromolith® RP-18 endcapped, L × I.D. 25 mm x 4.6 mm HPLC column

Materiali

PEEK column

Livello qualitativo

agenzia

suitable for USP L1

Nome Commerciale

Chromolith®

Caratteristiche

endcapped

Confezionamento

1 ea of

Grado di funzionalizzazione

18% Carbon loading

Parametri

200 bar pressure
45 °C max. temp.

tecniche

HPLC: suitable
LC/MS: suitable
mass spectrometry (MS): suitable (High)

Lungh. × diam. int. colonna

2.5 cm × 4.6 mm

Matrice

monolithic silica

Gruppo funzionale matrice

C18 bonding phase

Dimensione pori

13 nm mesoporosity
2 μm macroporosity

operating pH range

2-7.5

Tecnica di separazione

reversed phase

Temperatura di conservazione

no temp limit

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Descrizione generale

Chromolith® columns are made of monolithic silica with a characteristic bimodal pore structure.

Chromolith® Flash RP-18 endcapped columns have macropores with 2 μm diameter, giving a column efficiency exceeding 80,000 plates/meter. The mesopores are 13 nm (130 Å), the surface modification is octadecylsilane with full end-capping. Chromolith® Flash RP-18 endcapped columns fall under the USP L1 Classification. The column efficiency is comparable to a 5 μm particle size fully porous particulate column. Chromolith® Flash RP-18 endcapped columns are perfectly suitable for LC-MS applications.
The column dimension of 25 mm length and 4.6 mm I.D. is the best choice for very rapid separations on any HPLC System.

The revolutionary, monolithic silica with its unique combination of macropores and mesopores enables:
—Rapid separations at very low column back-pressure
—High matrix tolerance, allowing time and cost savings with simplified workflows
—Cost-savings due to extended column lifetimes
—Connection of columns, flow gradients and the use of mobile phases with higher viscosity

The recommended Guard-columns are:
Chromolith® RP-18 endcapped 5-4.6 guard cartridges (3 pieces) [1.51452] with the Chromolith® Guard Cartridge Holder 5 mm x 4.6 mm [1.52032]
Or
Chromolith® RP-18 endcapped 10-4.6 guard cartridges (3 pieces) [1.51451]
with the Chromolith® Guard Cartridge Holder 10 mm x 4.6 mm [1.52033]
The Chromolith® column coupler can be used to significantly increase the separation efficiency of Chromolith® columns by coupling several columns in series (up to 100,000 plates/per column). [1.51467]

Need more efficiency?
Chromolith® HighResolution RP-18 endcapped 25-4.6 HPLC columns [1.52020] provide a column efficiency exceeding 140,000 plates/meter.

Learn more:
Brochure: Race through your Separations on Any System. Chromolith® Monolithic Silica HPLC Columns

All Supelco HPLC Columns, including monolithic Chromolith® columns, are fully compatible to all HPLC and UHPLC Instruments.
Supelco HPLC Products: The Best Choice for Any LC Instrument

Applicazioni


  • Rapid Determination of 30 Polyphenols in Tongmai Formula: This study utilized the Chromolith® RP-18 endcapped column in a liquid chromatography-tandem mass spectrometry setup to analyze 30 polyphenolic compounds in a traditional Chinese medicine formula, demonstrating its application in pharmaceutical analysis and quality control of complex herbal formulations (Wang et al., 2017).

  • Ultra-fast gradient LC method for omeprazole analysis using a monolithic column: The Chromolith® RP-18 endcapped column was employed in an ultra-fast gradient liquid chromatography method for the analysis of omeprazole in enteric-coated pellets, highlighting its efficiency in pharmaceutical quality control and rapid method development (Borges et al., 2010).

Risultati analitici

Carbon content: 17.0 - 18.6 %
Pressure: ≤ 10 bar
stability testing: passes test
Performance (anthracene)
Theoretical Plates (N/m) (Anthracene): ≥ 80000
Capacity factor (Anthracene): 3.0 - 4.0
Tailing (USP): 0.90 - 1.55 %

Note legali

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificati d'analisi (COA)

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Articoli

Chromolith® HPLC and UHPLC columns are made from monolithic silica with a bimodal pore structure using sol-gel technology.

Monolithic silica HPLC columns enable high-throughput analysis at low back pressure without loss of separation efficiency or peak capacity.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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