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A0424

Sigma-Aldrich

Alverine citrate salt

Sinonimo/i:

N-Ethyl-3,3′-diphenyldipropylamine, NSC 35459

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About This Item

Formula empirica (notazione di Hill):
C20H27N · C6H8O7
Numero CAS:
5560-59-8
Peso molecolare:
473.56
Numero CE:
226-929-3
Numero MDL:
MFCD00035086
Codice UNSPSC:
12352100
ID PubChem:
57653816
NACRES:
NA.22

Stato

powder

Livello qualitativo

200

Stringa SMILE

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2

InChI

1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
RYHCACJBKCOBTJ-UHFFFAOYSA-N

Informazioni sul gene

human ... HNF4A(3172) , HTR1A(3350)

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Applicazioni

Used for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
018F0643V
018F0643

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Sigma-Aldrich

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Sigma-Aldrich

00090

Acetaldehyde ammonia trimer

Acqua standard 0,1% Certified Reference Material for coulometric Karl Fischer Titration 1 g ≙ 1 mg H₂O Aquastar®

Supelco

1.88051

Acqua standard 0,1%

Acqua standard 1% Certified Reference Material for volumetric Karl Fischer Titration 1 g ≙ 10 mg H₂O Aquastar®

Supelco

1.88052

Acqua standard 1%

Dibutilftalato 99%

Sigma-Aldrich

524980

Dibutilftalato

1-eptano solfonato di sodio

Sigma-Aldrich

H2766

1-eptano solfonato di sodio

Metformin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1084

Metformin hydrochloride

Mehmet Arhan et al.
World journal of gastroenterology, 10(15), 2303-2304 (2004-07-20)
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests
A Abysique et al.
Alimentary pharmacology & therapeutics, 13(4), 561-566 (1999-04-24)
Alverine citrate is commonly used in the treatment of painful affections of the colon. To determine whether alverine citrate acts on the vagal sensory endings. Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion
S A Mitchell et al.
Alimentary pharmacology & therapeutics, 16(6), 1187-1195 (2002-05-29)
Alverine citrate has been used in the treatment of irritable bowel syndrome for many years. To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.
A M Coelho et al.
The Journal of pharmacy and pharmacology, 53(10), 1419-1426 (2001-11-08)
Serotonin (5-HT) is considered as a major mediator causing hyperalgesia and is involved in inflammatory reactions and irritable bowel syndrome. Alverine citrate may possess visceral antinociceptive properties in a rat model of rectal distension-induced abdominal contractions. This study was designed
[Dynamics of clinical symptoms and indices of visceral sensitivity in patients with the irritated bowels syndrome treated with meteospasmyl].
P A Makarchuk et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (1)(1), 25-29 (2005-07-05)
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