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Y0000687

Alverine citrate salt

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

N-Ethyl-3,3′-diphenyldipropylamine, NSC 35459

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About This Item

Formula empirica (notazione di Hill):
C20H27N · C6H8O7
Numero CAS:
5560-59-8
Peso molecolare:
473.56
Numero MDL:
MFCD00035086
Codice UNSPSC:
41116107
ID PubChem:
329831097
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

alverine

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2

InChI

1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
RYHCACJBKCOBTJ-UHFFFAOYSA-N

Informazioni sul gene

human ... HNF4A(3172) , HTR1A(3350)

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Used for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Prodotti correlati

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Mehmet Arhan et al.
World journal of gastroenterology, 10(15), 2303-2304 (2004-07-20)
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests
A Abysique et al.
Alimentary pharmacology & therapeutics, 13(4), 561-566 (1999-04-24)
Alverine citrate is commonly used in the treatment of painful affections of the colon. To determine whether alverine citrate acts on the vagal sensory endings. Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion
S A Mitchell et al.
Alimentary pharmacology & therapeutics, 16(6), 1187-1195 (2002-05-29)
Alverine citrate has been used in the treatment of irritable bowel syndrome for many years. To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.
A M Coelho et al.
The Journal of pharmacy and pharmacology, 53(10), 1419-1426 (2001-11-08)
Serotonin (5-HT) is considered as a major mediator causing hyperalgesia and is involved in inflammatory reactions and irritable bowel syndrome. Alverine citrate may possess visceral antinociceptive properties in a rat model of rectal distension-induced abdominal contractions. This study was designed
[Dynamics of clinical symptoms and indices of visceral sensitivity in patients with the irritated bowels syndrome treated with meteospasmyl].
P A Makarchuk et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (1)(1), 25-29 (2005-07-05)
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