928380

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid

≥95%

• Formula empirica (notazione di Hill): C₁₈H₂₉N₅O₅
• Peso molecolare: 395.45
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Forma fisica: powder
• Impiego in reazioni chimiche: reagent type: linker
• Gruppo funzionale: Boc; amine; carboxylic acid
• Temperatura di conservazione: 2-8°C

Descrizione

Applicazioni

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.

Altre note

Technology Article: Degrader Building Blocks for Targeted Protein Degradation


Building PROTAC^® Degraders for Targeted Protein Degradation


Crosslinkers for Bioconjugation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable