921939

(S,R,S)-AHPC-pyrimidine-piperazine-PEG₁-NH₂ hydrochloride

• Sinonimo/i: 5-{4-[2-(2-Aminoethoxy)ethyl]piperazin-1-yl}-N-[(2R)-1-[(2R,4S)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]pyrimidine-2-carboxamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC^® research, Template for synthesis of targeted protein degrader, VH032 conjugate
• Formula empirica (notazione di Hill): C₃₅H₄₉N₉O₅S · xHCl
• Peso molecolare: 707.89 (free base basis)

Proprietà

• Forma fisica: solid
• Livello qualitativo: 100
• Impiego in reazioni chimiche: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• Gruppo funzionale: amine
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C([C@@H]1C[C@H](CN1C([C@H](C(C)(C)C)NC(C2=NC=C(C=N2)N3CCN(CC3)CCOCCN)=O)=O)O)NCC4=CC=C(C=C4)C5=C(N=CS5)C.[xHCl]

Descrizione

Applicazioni

Protein degrader building block (S,R,S)-AHPC-pyrimidine-piperazine-PEG₁-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable