901568

Bromo-PEG₃-acid

• Formula empirica (notazione di Hill): C₉H₁₇BrO₅
• Numero CAS: 782475-35-8
• Peso molecolare: 285.13
• Numero MDL: MFCD22574820
• Codice UNSPSC: 12352101
• NACRES: NA.22

Proprietà

• Forma fisica: liquid
• Impiego in reazioni chimiche: reagent type: linker
• Gruppo funzionale: bromo; carboxylic acid
• Temperatura di conservazione: −20°C
• Stringa SMILE: BrCCOCCOCCOCCC(O)=O

Descrizione

Applicazioni

Bromo-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3