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Documenti fondamentali

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725765

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one

95%

Sinonimo/i:

2-Methyl-3(2H)-isothiazolone

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About This Item

Formula empirica (notazione di Hill):
C4H5NOS
Numero CAS:
2682-20-4
Peso molecolare:
115.15
Beilstein:
606203
Numero CE:
220-239-6
Numero MDL:
MFCD01742315
Codice UNSPSC:
12352100
ID PubChem:
329764182
NACRES:
NA.21

Livello qualitativo

100

Saggio

≥94.0% (GC)
95%

Stato

lumps

Impurezze

≤5% water

Stringa SMILE

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3
BEGLCMHJXHIJLR-UHFFFAOYSA-N

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Applicazioni

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.: This study investigates the differential sensitivity of daphnids to 2-Methyl-4-isothiazolin-3-one, highlighting the biochemical mechanisms underlying these variations. The findings provide crucial insights for environmental safety assessments (Kim et al., 2023).
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.: The study assesses the impact of 2-Methyl-4-isothiazolin-3-one on regenerative processes in amphibians, contributing to the understanding of its biological effects and potential toxicity (Delos Santos et al., 2016).
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.: This review includes discussions on 2-Methyl-4-isothiazolin-3-one-induced contact dermatitis, providing valuable information for dermatological applications and safety assessments (Knackstedt and Zug, 2015).

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311,H314,H317,H330,H410

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

Rischi supp

EUH071

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCG6210
BCCG0710
BCCD9464
BCCD7472
BCBX1165

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4,5-dichloro-2-octyl-isothiazolone AldrichCPR

Sigma-Aldrich

CDS003259

4,5-dichloro-2-octyl-isothiazolone

5-Bromo-5-nitro-1,3-dioxane ≥99%

Sigma-Aldrich

B8791

5-Bromo-5-nitro-1,3-dioxane

ProClin™ 950 pkg of 17 L, ProClin™ preservative for use in IVD manufacturing, MIT 9.5 %

Sigma-Aldrich

46884-U

ProClin™ 950

A Spawn et al.
Neuroscience, 205, 194-204 (2012-01-17)
Methylisothiazolinone (MIT) is a commonly used biocide known to be neurotoxic in vitro. Brief exposure of cortical neurons in culture to MIT results in increased neurodegeneration, whereas chronic exposure of developing neurons in culture to low concentrations of MIT has
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Eleanor Higgins et al.
Dermatitis : contact, atopic, occupational, drug, 24(2), 73-76 (2013-03-12)
The isothiazolinones methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) are the active ingredients in a frequently used preservative in cosmetic, household, and industrial products. This study reviewed our department's cases of allergic contact dermatitis caused by MCI/MI, outlining their clinical presentation and possible
Mari Paz Castanedo-Tardana et al.
Dermatitis : contact, atopic, occupational, drug, 24(1), 2-6 (2013-01-24)
The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. Because the use of MI in cosmetics and toiletries in the United States rises, MI exposure also rises. Although it might seem likely
M D Lundov et al.
The British journal of dermatology, 165(6), 1178-1182 (2011-07-23)
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone
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