49920

Glycerol formal

≥98.0% (GC)

• Sinonimo/i: 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Formula empirica (notazione di Hill): C₄H₈O₃
• Numero CAS: 99569-11-6
• Peso molecolare: 104.10
• Beilstein: 103206
• Numero MDL: MFCD10039829
• Codice UNSPSC: 12352100
• ID PubChem: 57651229
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98.0% (GC)
• contiene: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• Composizione: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• Indice di rifrazione: n20/D 1.451 (lit.); n20/D 1.451
• P. eboll.: 192-193 °C (lit.)
• Densità: 1.203 g/mL at 25 °C (lit.)
• Gruppo funzionale: ether; hydroxyl
• Stringa SMILE: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2; JIUMSISXCKWZTA-UHFFFAOYSA-N

Descrizione

Descrizione generale

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Applicazioni

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

Informazioni sulla sicurezza

• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type ABEK (EN14387) respirator filter