361941

Di-tert-butyl dicarbonate

≥99%, for peptide synthesis, ReagentPlus^®

• Sinonimo/i: Boc anhydride, Di-tert-butyl pyrocarbonate
• Formula condensata: [(CH₃)₃COCO]₂O
• Numero CAS: 24424-99-5
• Peso molecolare: 218.25
• Beilstein: 1911173
• Numero CE: 246-240-1
• Numero MDL: MFCD00008805
• Codice UNSPSC: 12352302
• ID PubChem: 24862282
• NACRES: NA.22

Proprietà

• Nome del prodotto: Di-tert-butyl dicarbonate, ReagentPlus^®, ≥99%
• Livello qualitativo: 200
• Nome Commerciale: ReagentPlus^®
• Saggio: ≥99%
• Stato: solid or liquid
• Indice di rifrazione: n20/D 1.409 (lit.)
• P. ebollizione: 56-57 °C/0.5 mmHg (lit.)
• Punto di fusione: 23 °C (lit.)
• Densità: 0.95 g/mL at 25 °C (lit.)
• applicazioni: peptide synthesis
• Gruppo funzionale: carbonate
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
• InChI: 1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3; DYHSDKLCOJIUFX-UHFFFAOYSA-N

Descrizione

Applicazioni

Automated Boc protection and deprotection can be done using Synple Automated Synthesis Platform (SYNPLE-SC002), Boc protection cartridges ((SYNPLE-B001), (SYNPLE-B002), and Boc deprotection cartridges (SYNPLE-B011)

Di-tert-butyl dicarbonate (Boc anhydride) can be used:

• As a reagent to introduce Boc protecting group for the amine functionalities.
• To prepare tert-butyl ethers and Boc-alcohols in presence of Lewis acid catalyst.
• As a carboxylating agent for the preparation of a variety of tert-butyl carboxylates.
• For the conversion of amines to corresponding isocyanates, carbamates and urea derivatives.
• As a coupling reagent for anchoring various carboxylic acids to hydroxymethylated resins.
• To synthesize quinolinones and 2-(pseudo)haloquinolines from 2-alkenylanilines in presence of DMAP as a catalyst.

Reagent for the introduction of the Boc protecting group.

Attenzione

Hydrolyzes to t-butanol and CO₂; causes internal pressure in bottle if exposed to moisture.

Note legali

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H226,H315,H317,H318,H330,H335
• Consigli di prudenza: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 98.6 °F - closed cup
• Punto d’infiammabilità (°C): 37 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter