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15480

Sigma-Aldrich

Boc-Phe-OH

≥99.0% (T)

Sinonimo/i:

N-(tert-Butoxycarbonyl)-L-phenylalanine, Boc-L-phenylalanine

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About This Item

Formula condensata:
C6H5CH2CH(COOH)NHCOOC(CH3)3
Numero CAS:
13734-34-4
Peso molecolare:
265.30
Beilstein:
2219729
Numero CE:
237-305-5
Numero MDL:
MFCD00002663
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
24849476
NACRES:
NA.22

Saggio

≥99.0% (T)

Forma fisica

solid

Attività ottica

[α]20/D +25±1°, c = 1% in ethanol

Impiego in reazioni chimiche

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Punto di fusione

85-87 °C (lit.)

applicazioni

peptide synthesis

Gruppo funzionale

amine
carboxylic acid

Stringa SMILE

CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C14H19NO4/c1-14(2,3)19-13(18)15-11(12(16)17)9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m0/s1
ZYJPUMXJBDHSIF-NSHDSACASA-N

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Z-Phe-OH 99%

Sigma-Aldrich

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Z-Phe-OH

PAMAM-OH dendrimer, generation 5 solution generation 5, 5% in methanol

Sigma-Aldrich

536814

PAMAM-OH dendrimer, generation 5 solution

Boc-Tyr-OH 98%

Sigma-Aldrich

374229

Boc-Tyr-OH

Jie Chen et al.
Archives of pharmacal research, 37(1), 142-148 (2013-11-23)
Novel thermo- and pH-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (PEI) by grafting L-phenylalanine. The phenylalanine-modified PEI exhibited lower cytotoxicity than commercial PEI. These copolymers showed the phenomena of phase transitions in response to pH and temperature.
Xiaoxiong Han et al.
Journal of biomaterials science. Polymer edition, 27(7), 626-642 (2016-02-26)
Cabazitaxel (CTX) is a second-generation semisynthetic taxane that demonstrates antitumor activity superior to docetaxel. However, the low aqueous solubility of CTX has hampered its use as a therapeutic agent. In this work, CTX-loaded N-t-butoxycarbonyl-L-phenylalanine end-capped monomethyl poly (ethylene glycol)-block-poly (D,L-lactide)
Yasuhiro Tsume et al.
Molecular pharmaceutics, 5(5), 717-727 (2008-07-26)
Dipeptide monoester prodrugs of floxuridine were synthesized, and their chemical stability in buffers, resistance to glycosidic bond metabolism, affinity for PEPT1, enzymatic activation and permeability in cancer cells were determined and compared to those of mono amino acid monoester floxuridine
Yong Chen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 99, 103-113 (2015-12-22)
The objective was to investigate the topical iontophoretic delivery of a series of amino acid ester prodrugs of aciclovir (ACV-X, where ACV=aciclovir and X=Arg, Gly, Ile, Phe, Trp and Val) as a means to enhance cutaneous delivery of ACV. The
Matthew J Crawford et al.
Journal of nucleic acids, 2011, 652702-652702 (2011-07-22)
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations and hybridization properties of PNAs were determined
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