324671

Potassium bis(trimethylsilyl)amide

95%

• Sinonimo/i: Hexamethyldisilazane potassium salt, Potassium hexamethyldisilazide
• Formula condensata: [(CH₃)₃Si]₂NK
• Numero CAS: 40949-94-8
• Peso molecolare: 199.48
• Beilstein: 4006754
• Numero MDL: MFCD00010330
• Codice UNSPSC: 12352111
• ID PubChem: 24859460
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Saggio: 95%
• Stato: solid
• Densità: 0.877 g/cm³ at 20 °C
• Stringa SMILE: C[Si](C)(C)N([K])[Si](C)(C)C
• InChI: 1S/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1; IUBQJLUDMLPAGT-UHFFFAOYSA-N

Descrizione

Descrizione generale

Potassium bis(trimethylsilyl)amide is commonly abbreviated as KHMDS with molecular formula [(CH₃)₃Si]₂NK. It is widely used as Bronsted base in synthesis.

KHMDS is a base catalyst, that shows high activity and selectivity for the alkylation of alkylpyridines.

Applicazioni

Anionic initiator used in the preparation of poly(ethylene oxide). Sterically hindered base employed in selective cyclization reactions. Also used in the preparation of lanthanide complexes.

Caratteristiche e vantaggi

Potassium bis(trimethylsilyl)amide (KHMDS):

• Easily available.
• Good selectivity for the benzylic C−H bonds.
• Good reactivity for sterically crowded C−H bonds.

Informazioni sulla sicurezza

• Pittogrammi: GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H314
• Consigli di prudenza: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classi di pericolo: Eye Dam. 1 - Skin Corr. 1B
• Rischi supp: EUH014
• Codice della classe di stoccaggio: 8A - Combustible corrosive hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges