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440191

Sigma-Aldrich

Hexamethyldisilazane

reagent grade, ≥99%

Sinonimo/i:

Bis(trimethylsilyl)amine, HMDS

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About This Item

Formula condensata:
(CH3)3SiNHSi(CH3)3
Numero CAS:
999-97-3
Peso molecolare:
161.39
Beilstein:
635752
Numero CE:
213-668-5
Numero MDL:
MFCD00008259
Codice UNSPSC:
12352103
ID PubChem:
24867576
NACRES:
NA.23

Grado

reagent grade

Saggio

≥99%

Stato

liquid

Indice di rifrazione

n20/D 1.407 (lit.)

P. ebollizione

125 °C (lit.)

Stringa SMILE

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
FFUAGWLWBBFQJT-UHFFFAOYSA-N

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Descrizione generale

Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.

Applicazioni

Hexamethyldisilane (HMDS) can be used:
  • As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
  • To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
  • To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
  • For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.

Caratteristiche e vantaggi

  • High chemicalstability and low molecular weight
  • Nontoxic andcost-effective reagent
  • Ammonia is theonly byproduct generated during silylation
  • Silylationreaction using HDMS is nearly neutral and does not need any precaution

Pittogrammi

FlameSkull and crossbones
GHS02,GHS06

Avvertenze

Danger

Indicazioni di pericolo

H225,H302 + H332,H311,H412

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

52.5 °F - closed cup

Punto d’infiammabilità (°C)

11.4 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
STBK6647
STBK4817
STBK4303
STBK3387
STBK2705

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Lithium bis(trimethylsilyl)amide 97%

Sigma-Aldrich

324620

Lithium bis(trimethylsilyl)amide

Chlorotrimethylsilane purified by redistillation, ≥99%

Sigma-Aldrich

386529

Chlorotrimethylsilane

Hexamethyldisilathiane synthesis grade

Sigma-Aldrich

283134

Hexamethyldisilathiane

Sodium bis(trimethylsilyl)amide 95%

Sigma-Aldrich

235083

Sodium bis(trimethylsilyl)amide

F Braet et al.
Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS
Rapid and highly efficient trimethylsilylation of alcohols and phenols
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
Eskandar K, et al.
Journal of Chemical Sciences (Bangalore), 123(5), 703-708 (2011)
Svatopluk Civiš et al.
Scientific reports, 6, 23199-23199 (2016-03-17)
Recent synthetic efforts aimed at reconstructing the beginning of life on our planet point at the plausibility of scenarios fueled by extraterrestrial energy sources. In the current work we show that beyond nucleobases the sugar components of the first informational
Clyde Savio Pinto et al.
Scientific reports, 9(1), 12191-12191 (2019-08-23)
Apical projections are integral functional units of epithelial cells. Microvilli and stereocilia are cylindrical apical projections that are formed of bundled actin. Microridges on the other hand, extend laterally, forming labyrinthine patterns on surfaces of various kinds of squamous epithelial
Ashang Luwang Laiva et al.
International journal of pharmaceutics, 483(1-2), 115-123 (2015-02-15)
Electrospun hybrid nanofibrous scaffolds have gained much importance in the field of tissue engineering and drug delivery applications owing to its multifaceted properties. In this study, the properties of composite polycaprolactone (PCL)/silk fibroin (SF) nanofibrous scaffolds was investigated as a
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