386529

Chlorotrimethylsilane

purified by redistillation, ≥99%

• Sinonimo/i: TMSCl, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
• Formula condensata: (CH₃)₃SiCl
• Numero CAS: 75-77-4
• Peso molecolare: 108.64
• Beilstein: 1209232
• Numero CE: 200-900-5
• Numero MDL: MFCD00000502
• Codice UNSPSC: 12352302
• ID PubChem: 24864097
• NACRES: NA.22

Proprietà

• Densità del vapore: 3.7 (vs air)
• Livello qualitativo: 200
• Tensione di vapore: 100 mmHg ( 25 °C)
• Saggio: ≥99%
• Stato: liquid
• Temp. autoaccensione: 752 °F
• Purificato mediante: glass distillation; redistillation
• Limite di esplosione: 6.4 %
• Impurezze: <0.1% dichlorodimethylsilane
• Indice di rifrazione: n20/D 1.387 (lit.)
• P. ebollizione: 57 °C (lit.)
• Punto di fusione: −40 °C (lit.)
• Densità: 0.856 g/mL at 25 °C (lit.)
• Stringa SMILE: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3; IJOOHPMOJXWVHK-UHFFFAOYSA-N

Descrizione

Descrizione generale

Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.

Applicazioni

Chlorotrimethylsilane (TMSCl) can be used as:       

• A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.      
• A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.        
• A trapping agent for the anions generated during acyloin condensation reaction.       
• A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
•  A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.        
• A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.       
• A reagent in Fischer glycosidation.       
• A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et₃SiH.
• A reagent to synthesize sodium trimethylsilanethiolate (Me₃SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me₃SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H331,H312,H314
• Consigli di prudenza: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Rischi supp: EUH014
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): -18.4 °F - closed cup
• Punto d’infiammabilità (°C): -28 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles