296813

Sodium cyanoborohydride solution

1.0 M in THF

• Sinonimo/i: Sodium borocyanohydride, Sodium cyanoborohydride, Sodium cyanotrihydroborate
• Formula condensata: NaBH₃CN
• Numero CAS: 25895-60-7
• Peso molecolare: 62.84
• Numero MDL: MFCD00003516
• Codice UNSPSC: 12352306
• ID PubChem: 24857879
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Impiego in reazioni chimiche: reagent type: reductant
• Concentrazione: 1.0 M in THF
• Solubilità: THF: soluble(lit.); alcohol: soluble(lit.); hydrocarbons: insoluble(lit.); water: soluble(lit.)
• Densità: 0.915 g/mL at 25 °C
• Stringa SMILE: [Na+].[H][B-]([H])([H])C#N
• InChI: 1S/CH3BN.Na/c2-1-3;/h2H3;/q-1;+1; CVDUGUOQTVTBJH-UHFFFAOYSA-N

Descrizione

Descrizione generale

Sodium cyanoborohydride is a versatile reducing agent stable in aqueous solution at pH 7.2. It is a weaker reducing agent as compared to NaBH₄. It effectively reduces Schiff bases. NaCNBH₄ participates in the reductive methylation for the efficient and selective conversion of the e-amino groups of lysyl residues in proteins to the mono- and dimethyl derivatives.

Applicazioni

Reactant for:

• Direct conversion of heterocyclic aldehydes to esters (oxidizing behavior)
• Reductive amination reactions
• Intramolecular reductive cyclization reactions
• Reductions reactions
• Preparation of dicyanoborate-based ionic liquids as hypergolic fluids for bipropellants

Sodium cyanoborohydride may be used in the following studies:

• As reducing agent for the in vitro radiolabeling of proteins by reductive alkylation.
• Reduction of aldehydes and ketones.
• Selective deoxygenation of aldehydes and ketones.
• Preparation of colloidal gold particles of varying sizes.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08,GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H260,H301 + H311 + H331,H314,H335,H336,H351,H410
• Consigli di prudenza: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3 - Water-react 1
• Organi bersaglio: Central nervous system, Respiratory system
• Rischi supp: EUH019
• Codice della classe di stoccaggio: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): -4.0 °F
• Punto d’infiammabilità (°C): -20 °C