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Merck
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Documenti

123323

Sigma-Aldrich

Quinazoline

99%

Sinonimo/i:

1,3-Benzodiazine, Benzopyrimidine

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About This Item

Formula empirica (notazione di Hill):
C8H6N2
Numero CAS:
253-82-7
Peso molecolare:
130.15
Beilstein:
109370
Numero CE:
205-965-3
Numero MDL:
MFCD00006712
Codice UNSPSC:
12352100
ID PubChem:
24847559
NACRES:
NA.22

Saggio

99%

Forma fisica

solid

P. eboll.

243 °C (lit.)

Punto di fusione

46-48 °C (lit.)

Solubilità

H2O: freely soluble
organic solvents: soluble

Stringa SMILE

c1ccc2ncncc2c1

InChI

1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
JWVCLYRUEFBMGU-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Applicazioni

Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.

Azioni biochim/fisiol

Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

222.8 °F - closed cup

Punto d’infiammabilità (°C)

106 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Zhijiang Fan et al.
Molecular diversity, 22(3), 657-667 (2018-03-27)
A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1H-1,2,4-triazol-5-amine derivatives (7a-7r) were designed and synthesized based on a pharmacophore hybrid approach, and screened for their antibacterial and antifungal activities in vitro. All the target compounds were fully characterized through [Formula: see text]H NMR
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Siva Jyothi Buggana et al.
Computational biology and chemistry, 79, 110-118 (2019-02-21)
Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series
Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Reddy Amala et al.
BioImpacts : BI, 11(1), 15-22 (2021-01-21)
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and
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