12255
1,2-Benzisoxazole
≥95.0%
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About This Item
Formula empirica (notazione di Hill):
C7H5NO
Numero CAS:
Peso molecolare:
119.12
Beilstein:
2154
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Saggio
≥95.0%
Indice di rifrazione
n20/D 1.561 (lit.)
n20/D 1.563
P. eboll.
90-92 °C/15 mmHg (lit.)
Densità
1.174 g/mL at 25 °C (lit.)
Temperatura di conservazione
2-8°C
Stringa SMILE
c1ccc2oncc2c1
InChI
1S/C7H5NO/c1-2-4-7-6(3-1)5-8-9-7/h1-5H
KTZQTRPPVKQPFO-UHFFFAOYSA-N
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Categorie correlate
Descrizione generale
1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
186.8 °F - closed cup
Punto d’infiammabilità (°C)
86 °C - closed cup
Dispositivi di protezione individuale
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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D H Peters et al.
Drugs, 45(5), 760-787 (1993-05-01)
Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification
W Gristwood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 18(8), 949-954 (1988-08-01)
1. Twelve oxygen and sulphur azaheterocycles were studied as potential substrates of rabbit liver aldehyde oxidase. Only benzoxazole and 1,2-benzisoxazole were found to be substrates. 2. Nine of the compounds inhibited the oxidation of quinazoline by aldehyde oxidase and in
Nan-Sook Hong et al.
Nature communications, 9(1), 3900-3900 (2018-09-27)
Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the
Avneet Kaur et al.
Archiv der Pharmazie, 351(6), e1800008-e1800008 (2018-05-10)
A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced
Min Bao et al.
International journal of biological macromolecules, 137, 537-544 (2019-06-25)
Studies on endo-inulinases from yeast are scarce, compared to those from other microbial sources. In this study, a novel endo-inulinase from Lipomyces starkeyi NRRL Y-11557 was identified, expressed in its soluble form, and characterized its physicochemically properties, together with its
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