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Merck
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Key Documents

Altri documenti

109185

Sigma-Aldrich

Saccharin

≥98%

Sinonimo/i:

2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Formula empirica (notazione di Hill):
C7H5NO3S
Numero CAS:
81-07-2
Peso molecolare:
183.18
Beilstein:
6888
Numero CE:
201-321-0
Numero MDL:
MFCD00005866
Codice UNSPSC:
12352100
ID PubChem:
24846892
NACRES:
NA.22

Livello qualitativo

100

Saggio

≥98%

Punto di fusione

226-229 °C (lit.)

Solubilità

H2O: soluble 1g in 290ml
acetone: soluble 1g in 12ml
alcohol: soluble 1g in 31ml
boiling water: soluble 1g in 25ml
glycerol: soluble 1g in 50ml
alcohol: very slightly soluble
chloroform: slightly soluble
diethyl ether: slightly soluble

Stringa SMILE

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

Saccharin was used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame. It was used in sweet preference test of rats.

Azioni biochim/fisiol

Dietery administration of saccharin after N-methyl-N′-nitro-N-nitrosoguanidine promotes tumor development in rats.
A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Anne Marie Vinggaard et al.
Toxicological sciences : an official journal of the Society of Toxicology, 85(2), 886-897 (2005-03-25)
Prochloraz is a commonly used fungicide that has shown multiple mechanisms of action in vitro. It antagonizes the androgen and the estrogen receptors, agonizes the Ah receptor, and inhibits aromatase activity. In vivo prochloraz acts antiandrogenically in the Hershberger assay
Simultaneous determination of artificial sweeteners in possible counterfeited wines, using high performance liquid chromatography with DAD detection.
Geana EI, et al.
Analele Universitatii Ovidius din Constanta-Seria Chimie, 23(1), 77-81 (2012)
M Takahashi et al.
Gan, 75(6), 494-501 (1984-06-01)
Sodium chloride, saccharin sodium, phenobarbital sodium and aspirin were tested for tumor-promoting activity in the glandular stomach of rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) coupled with administration of a high salt diet. Male outbred Wistar rats were given MNNG in
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
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