NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Sinonimi:
GCCR, GCR, GR, GRL
Specie:
Human NR3C1 (2908), Mouse Nr3c1 (14815), Rat Nr3c1 (24413), Zebrafish nr3c1 (553740), chicken NR3C1 (416343), dog NR3C1 (478047), domestic cat NR3C1 (692348), cow NR3C1 (281946), Horse NR3C1 (100061217), domestic cat NR3C1 (101080939) ...Più
ID UniProtKB:
ID gene:
- Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- Mouse(14815) nuclear receptor subfamily 3, group C, member 1
- Rat(24413) nuclear receptor subfamily 3, group C, member 1
- Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
- naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Activator
Small Molecule - Agonist
N° Catalogo
Descrizione
Specie
Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
Hydrocortisone 21-hemisuccinate sodium salt, powder, BioReagent, suitable for cell culture,
Specie
human
Small Molecule - Antagonist
N° Catalogo
Descrizione
Specie
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-GR antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-NR3C1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-Glucocorticoid Receptor (Ab-2) Mouse mAb (BuGR2), lyophilized, clone BuGR2, Calbiochem®,
Reattività con
guinea pig, mouse, rabbit, rat, sheep
Applicazione
Anti-phospho-Glucocorticoid receptor Antibody, Ser226, from rabbit, purified by affinity chromatography,
Reattività con
human, mouse, rat
Applicazione
western blot
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
Reattività con
bovine, canine, feline, horse, human, mouse, nonhuman primates
Applicazione
affinity binding assay
western blot
western blot
Small Molecule - Mixed Agonist/Antagonist
N° Catalogo
Descrizione
Specie
Desametasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Specie
mouse, rat, human