Passa al contenuto
Merck
Tutte le immagini(4)

Key Documents

Altri documenti

D1159

Sigma-Aldrich

Dexamethasone 21-phosphate disodium salt

≥98%

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(4)

About This Item

Formula empirica (notazione di Hill):
C22H28FNa2O8P
Numero CAS:
2392-39-4
Peso molecolare:
516.40
Beilstein:
6473066
Numero CE:
219-243-0
Numero MDL:
MFCD00079105
Codice UNSPSC:
51422340
ID PubChem:
24893369
NACRES:
NA.25

Saggio

≥98%

Forma fisica

powder

Impurezze

≤1% ethanol

Colore

white to off-white

Temperatura di conservazione

2-8°C

Stringa SMILE

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
PLCQGRYPOISRTQ-FCJDYXGNSA-L

Informazioni sul gene

human ... NR3C1(2908)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Dexamethasone 21-phosphate disodium salt has been used:
  • as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models
  • as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice
  • to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Azioni biochim/fisiol

Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes. It exhibits therapeutic effects against cystic fibrosis and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H361d

Classi di pericolo

Acute Tox. 4 Oral - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

Desametasone meets USP testing specifications

Sigma-Aldrich

D9184

Desametasone

Dexamethasone 21-acetate ≥99%

Sigma-Aldrich

D1881

Dexamethasone 21-acetate

Dexamethasone solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-085

Dexamethasone solution

Fludrocortisone acetate ≥98%

Sigma-Aldrich

F6127

Fludrocortisone acetate

Desametasone powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Sigma-Aldrich

D8893

Desametasone

Desametasone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1526

Desametasone

Betametasone 21-fosfato ≥97%

Sigma-Aldrich

B7652

Betametasone 21-fosfato

Katja A Lamia et al.
Nature, 480(7378), 552-556 (2011-12-16)
Mammalian metabolism is highly circadian and major hormonal circuits involving nuclear hormone receptors display interlinked diurnal cycling. However, mechanisms that logically explain the coordination of nuclear hormone receptors and the clock are poorly understood. Here we show that two circadian
Amy E Cohen et al.
Ophthalmology, 119(1), 66-73 (2011-11-26)
Determine safe, effective, iontophoretic dose(s) of EGP-437 (dexamethasone phosphate formulated for iontophoresis) in patients with noninfectious anterior uveitis; evaluate systemic drug exposures. Prospective, phase I/II, multicenter, double-masked, parallel group, randomized clinical trial. Forty outpatients with anterior uveitis. Forty of 42
Parawee Rattanakit et al.
International journal of pharmaceutics, 422(1-2), 254-263 (2011-11-22)
A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through
Andrew M McMillan et al.
BMJ (Clinical research ed.), 344, e3260-e3260 (2012-05-24)
To investigate the effectiveness of ultrasound guided corticosteroid injection in the treatment of plantar fasciitis. Randomised, investigator and participant blinded, placebo controlled trial. University clinic in Melbourne, Australia. 82 people with a clinical and ultrasound diagnosis of plantar fasciitis unrelated
Kang Ho Kim et al.
Molecular endocrinology (Baltimore, Md.), 30(8), 905-916 (2016-06-30)
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in permanent liver damage. Upon liver damage, nonparenchymal cells
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.