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Merck
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Documenti

D1881

Sigma-Aldrich

Dexamethasone 21-acetate

≥99%

Sinonimo/i:

9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Formula empirica (notazione di Hill):
C24H31FO6
Numero CAS:
1177-87-3
Peso molecolare:
434.50
Beilstein:
2342608
Numero CE:
214-646-8
Numero MDL:
MFCD00027407
Codice UNSPSC:
51422333
ID PubChem:
24893562
NACRES:
NA.77

Saggio

≥99%

Forma fisica

powder

Temperatura di conservazione

2-8°C

Stringa SMILE

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
AKUJBENLRBOFTD-RPRRAYFGSA-N

Informazioni sul gene

human ... NR3C1(2908)

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Applicazioni

Dexamethasone 21-acetate has been used:
  • as a component of the induction medium for the treatment of mice preadipocytes (5A) cells
  • as a synthetic glucocorticoid to study its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in placentas of human and mice
  • as a component of the complete medium for the culturing of porcine hepatocytes

Azioni biochim/fisiol

Dexamethasone 21-acetate or dexamethasone acetate is a derivative of dexamethasone. It is a hydrophobic drug. Dexamethasone is a glucocorticoid possessing anti-inflammatory activity.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360FD

Classi di pericolo

Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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3-isobutil-1-metilxantina

M Alexandrová et al.
Endocrinologia experimentalis, 22(3), 171-179 (1988-09-01)
Rapid fall in the amount of glucocorticoid cytosol receptor in target tissues is considered to be a consequence of the receptor translocation to nuclei. The effect of single injection of synthetic (dexamethasone 21-acetate) and natural (corticosterone) glucocorticoid on the depletion
Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels
Carrer1 A, et al.
The Journal of Biological Chemistry, 5(1-2), 487-487 (2017)
Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media
Caperna T J, et al.
In Vitro Cellular & Developmental Biology. Animal, 47(3), 218-233 (2011)
F Ceccato et al.
Journal of endocrinological investigation, 43(8), 1105-1113 (2020-02-16)
Dexamethasone Suppression Test (DST), recommended for Cushing's Syndrome (CS) diagnosis, explores the pituitary feedback to glucocorticoids. Its diagnostic accuracy could be affected by dexamethasone bioavailability, and therefore, we have developed and validated a dexamethasone threshold after 1-mg DST. We studied
T Lifshitz et al.
Ophthalmic surgery and lasers, 32(2), 159-161 (2001-04-13)
Retrocorneal membranes after penetrating keratoplasty (PKP) is a well known complications, resulting from unintentional retention of the host Descemet's membrane (DM), or donor DM detachment. We describe for the first time the formation of a retrocorneal inflammatory membrane that mimics
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