O9389

Oltipraz

≥98% (HPLC), powder

• Synonym(e): 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972
• Empirische Formel (Hill-System): C₈H₆N₂S₃
• CAS-Nummer: 64224-21-1
• Molekulargewicht: 226.34
• EG-Nummer: 264-736-6
• MDL-Nummer: MFCD00868499
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818939
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: red
• Löslichkeit: DMSO: >20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CC1=C(SSC1=S)c2cnccn2
• InChI: 1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
• InChIKey: CKNAQFVBEHDJQV-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.

Biochem./physiol. Wirkung

Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves