M5324

PX 12

≥98% (HPLC), powder

• Synonym(e): 2-[(1-methylpropyl)dithio]-1H-imidazole
• Empirische Formel (Hill-System): C₇H₁₂N₂S₂
• CAS-Nummer: 141400-58-0
• Molekulargewicht: 188.31
• MDL-Nummer: MFCD18086851
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818011
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to tan
• Löslichkeit: DMSO: >25 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCC(C)SSc1ncc[nH]1
• InChI: 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
• InChIKey: BPBPYQWMFCTCNG-UHFFFAOYSA-N

Beschreibung

Anwendung

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.

Biochem./physiol. Wirkung

PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable