D9035

Diazoxid

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

• Synonym(e): 7-Chlor-3-methyl-2H-1,2,4-benzothiadiazin-1,1-dioxid
• Empirische Formel (Hill-System): C₈H₇ClN₂O₂S
• CAS-Nummer: 364-98-7
• Molekulargewicht: 230.67
• EG-Nummer: 206-668-1
• MDL-Nummer: MFCD00078578
• UNSPSC-Code: 12352119
• PubChem Substanz-ID: 24277831
• NACRES: NA.77

Eigenschaften

• product name: Diazoxid,
• Form: powder
• Qualitätsniveau: 100
• Löslichkeit: 0.1 M NaOH: soluble; H₂O: insoluble; methanol: soluble
• Ersteller: Schering Plough
• SMILES String: CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
• InChI: 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
• InChIKey: GDLBFKVLRPITMI-UHFFFAOYSA-N
• Angaben zum Gen: human ... KCNA1(3736) , KCNJ11(3767) , KCNJ8(3764) , KCNMA1(3778) ; mouse ... Kcnj1(56379) , Kcnj11(16514) ; rat ... Gria1(50592) , Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj8(25472)

Beschreibung

Allgemeine Beschreibung

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell K_ATP channel opener. Diazoxide prevents the secretion of insulin.

Anwendung

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K⁺-induced exocytosis.

Biochem./physiol. Wirkung

Selective ATP-sensitive K⁺ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves