[Distinctive features of the anxiety state development in experimental model of posttraumatic stress disorder in the prenatally stressed male rats].

Anxious-depressive state was studied in experimental "stress-restress" model of posttraumatic stress disorder (PTSD) using adult rat males. Rat males were born by control females and whose mothers were under 60-minute immobilization stress since 15 until 19 days of pregnancy. Then rats were exposed to a single session of prolonged stress (restraint followed by a forced swim and exposure to ether vapors) and restressed 7 days later. 10 and 20 days after restress animals were tested in elevated plus-maze to measure anxiety and forced swim test to research depression-like behavior. In both groups there were control animal that stay intact. In addition to behavior, we studied activity of hypothalamo-pituitary-adrenal axis (basal activity and fast feedback inhibition) by analysis of plasma corticosterone concentration. We found that in control and prenatally stressed (PS) rat males in 10 days after stress have pathological state such as elevated anxiety and depressive-like behavior and inhibition of stress activity of H PA axis due to activation of fast feedback. However, in PS rats signs of disorder were deeper and longer--decreased basal plasma corticosterone and increased anxiety those saved in 20 days after restress. In conclusion, we can say that prenatal stress promotes developing of stronger behavioral and hormonal pathology in "stress-restress" paradigm.