1096724

Carmustine

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Fórmula empírica (Notação de Hill): C₅H₉Cl₂N₃O₂
• Número CAS: 154-93-8
• Peso molecular: 214.05
• Número MDL: MFCD00057706
• Código UNSPSC: 41116107
• ID de substância PubChem: 329749246
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: carmustine
• Formulário: (Oily liquid to amorphous solid)
• fabricante/nome comercial: USP
• pf: 30 °C (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• chave InChI: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Informações sobre genes: human ... GSR(2936)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

• Enhancing glioblastoma treatment: Overexpression of Let-7a-3p in U87MG glioblastoma cells enhances chemosensitivity to Carmustine, promoting autophagy and suppressing cell survival, suggesting its role in improving outcomes in glioblastoma multiforme treatment using antineoplastic alkylating compounds (Bahojb Mahdavi et al., 2024).


• Pharmacogenomic profiling in renal cancer: Characterization of mitoribosomal small subunit genes in renal cell carcinoma reveals significant implications for Carmustine′s pharmacogenomic interaction, enhancing understanding of its mechanism in cancer therapy and providing a basis for personalized treatment approaches (Wei et al., 2024).

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H300,H350,H360
• Declarações de precaução: P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
• Classificações de perigo: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable