U103

U-69593

solid

• Sinônimo(s): (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide, U69593
• Fórmula empírica (Notação de Hill): C₂₂H₃₂N₂O₂
• Número CAS: 96744-75-1
• Peso molecular: 356.50
• Número MDL: MFCD05664586
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278769
• NACRES: NA.77

Propriedades

• Formulário: solid
• Nível de qualidade: 100
• atividade óptica: [α]/D +7.8°, c = 0.825 in methanol(lit.)
• cor: white
• solubilidade: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL; 0.1 M HCl: >40 mg/mL; ethanol: >40 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccccc4
• InChI: 1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1
• chave InChI: PGZRDDYTKFZSFR-ONTIZHBOSA-N
• Informações sobre genes: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) ; mouse ... Oprk1(18387) ; rat ... Oprd1(24613) , Oprk1(29335) , Oprm1(25601)

Descrição

Ações bioquímicas/fisiológicas

U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

U-69593 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (10 mg/ml), 0.1 M HCl (>40 mg/ml), and ethanol (>40 mg/ml). However, it is insoluble in 0.1 M NaOH and water.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)