T6154

Trazodone hydrochloride

≥99% (HPLC), powder

• Sinônimo(s): 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
• Fórmula empírica (Notação de Hill): C₁₉H₂₂ClN₅O · HCl
• Número CAS: 25332-39-2
• Peso molecular: 408.32
• Número CE: 246-855-5
• Número MDL: MFCD00079603
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278136
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥99% (HPLC)
• Formulário: powder
• solubilidade: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3 mg/mL; methanol: soluble 25 mg/mL, clear, colorless; 0.1 M HCl: soluble 7.4 mg/mL; DMSO: soluble; H₂O: soluble, hazy, colorless
• originador: Bristol-Myers Squibb
• cadeia de caracteres SMILES: Cl[H].Clc1cccc(c1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2
• InChI: 1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H
• chave InChI: OHHDIOKRWWOXMT-UHFFFAOYSA-N
• Informações sobre genes: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2C(3358) , SLC6A4(6532)

Descrição

Ações bioquímicas/fisiológicas

Antidepressant that potentiates the activity of serotonin uptake blockers and has full 5-HT_2C serotonin receptor agonist activity. It is metabolized to the 5-HT₁ serotonin receptor agonist 1-(3-Chlorophenyl)piperazine.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

Trazodone hydrochloride dissolves in methanol at 25 mg/ml to yield a clear, colorless solution. It also dissolves in water at 50 mg/ml, with heating to yield a hazy colorless solution. Furthermore, the product is soluble in DMSO or in 0.1 N HCl (7.4 mg/ml). The solubility in a 45% (w/v) aqueous 2-hydroxpropyl-β-cyclodextrin is 23.3 mg/ml. However, it is practically insoluble in other common organic solvents. For HPLC test, the product can be dissolved at 0.25 mg/ml in 50:50 water:methanol (v/v), as this gives better results of dissolution and peak shape than using the product as a 1 mg/ml solution in water.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H351
• Declarações de precaução: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classificações de perigo: Acute Tox. 4 Oral - Carc. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges