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T3955

Sigma-Aldrich

TNP

≥95% (HPLC)

Sinônimo(s):

N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine

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About This Item

Fórmula empírica (Notação de Hill):
C20H16F3N7O2
Número CAS:
519178-28-0
Peso molecular:
443.38
Número MDL:
MFCD16875436
Código UNSPSC:
12352200
ID de substância PubChem:
329826781
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥95% (HPLC)

forma

powder

condição de armazenamento

protect from light

cor

yellow

solubilidade

DMSO: ≥10 mg/mL

originador

Novartis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

chave InChI

DDSBPUYZPWNNGH-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.

Características e benefícios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

TNP is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Maxime Dupin et al.
PloS one, 6(6), e20957-e20957 (2011-06-28)
Many distribution models developed to predict the presence/absence of invasive alien species need to be fitted to a training dataset before practical use. The training dataset is characterized by the number of recorded presences/absences and by their geographical locations. The
Joerg U Eberle et al.
The Journal of investigative dermatology, 139(9), 1957-1965 (2019-03-27)
The mechanisms leading to allergic skin inflammation, such as atopic dermatitis or urticaria, are poorly defined. Here we used a mouse model for IgE-dependent chronic allergic inflammation to study the role of basophils and eosinophils for induction of pathology. FcεRI
Takashi Nakagata et al.
Medicina (Kaunas, Lithuania), 55(7) (2019-07-10)
Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs)
Jo-Anne E Cavanagh et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 342-349 (2018-02-11)
The use of biosolids as a soil conditioner and fertiliser is hindered by the limited knowledge on the risks of micro-contaminants they contain. This study investigated the binding of six organic contaminants commonly found in biosolids, to the estrogen (ER)
Natalie E Nieuwenhuizen et al.
PLoS neglected tropical diseases, 7(8), e2395-e2395 (2013-09-07)
Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, we generated a monoclonal antibody (48Eg) against haemoglobin
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