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T1270

Sigma-Aldrich

Tiamina

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sinônimo(s):

Aneurina, Vitamina B1

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About This Item

Fórmula empírica (Notação de Hill):
C12H17ClN4OS · HCl
Número CAS:
67-03-8
Peso molecular:
337.27
Beilstein:
3851771
Número CE:
200-641-8
Número MDL:
MFCD00012780
Código UNSPSC:
12352207
eCl@ss:
34058006
ID de substância PubChem:
24899952
NACRES:
NA.75

fonte biológica

synthetic (organic)

Nível de qualidade

200

linha de produto

BioReagent

Ensaio

≥99.0% (HPLC)

forma

powder

peso molecular

Mw 337.27 g/mol

técnica(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

cor

white

pf

250 °C (dec.) (lit.)

solubilidade

H2O: 50 mg/mL, clear, colorless

aplicação(ões)

agriculture

cadeia de caracteres SMILES

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

chave InChI

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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Descrição geral

Thiamine or Vitamin B1 is a positively charged and essential constituent for all tissues. It is present at higher levels in skeletal muscles, liver, kidney, heart, and brain. Thiamine is composed of a pyrimidine ring linked to a thiazole ring via a methylene bridge.

Aplicação

Thiamine hydrochloride has been used as a component:
  • of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii
  • of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis
  • of modified Bold 3N medium for culturing Chlorella minutissima

Ações bioquímicas/fisiológicas

Thiamine is converted to thiamine diphosphate post-movement into the cellular membranes by thiamine diphosphokinase. Thiamine diphosphate, an active cofactor is essential for the mechanism of many enzymes involved in the citric acid cycle, the glycolytic pathway, the degradation of branched-chain amino acids, and the pentose phosphate pathway. Thiamine is involved in converting food into energy required for functioning the central and peripheral nervous systems. Lower levels of this vitamin are associated with delirium, Wernicke′s encephalopathy, and Wernicke-Korsakoff syndrome. Thiamine hydrochloride is required to support energy metabolism and amino acid synthesis in cultured cells. It is present in many classical and serum-free formulations.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H319

Classificações de perigo

Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

I7508

mio-inositol

Tiamina 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-014

Tiamina

(−)-Riboflavina BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sigma-Aldrich

R9504

(−)-Riboflavina

D-Pantothenic acid hemicalcium salt BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sigma-Aldrich

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Piridoxina ≥98% (HPLC)

Sigma-Aldrich

P9755

Piridoxina

Pyridoxine ≥98%

Sigma-Aldrich

P5669

Pyridoxine

Zsigmond Benko et al.
Current HIV research, 17(6), 429-440 (2019-11-30)
HIV-1 protease inhibitor (PI) is one of the most potent classes of drugs in combinational antiretroviral therapies (cART). When a PI is used in combination with other anti- HIV drugs, cART can often suppress HIV-1 below detection thus prolonging the
A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst
Lei M, et al.
Tetrahedron Letters, 51(32), 4186-4188 (2010)
Cinzia Fino et al.
MicrobiologyOpen, 9(8), e1064-e1064 (2020-06-20)
Antibiotic-tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive. Controversies revolve around the relative contribution of specific genetic switches called toxin-antitoxin (TA) modules and global modulation of
Roshali T de Silva et al.
Microbiology (Reading, England), 167(2) (2021-01-19)
Some microbes display pleomorphism, showing variable cell shapes in a single culture, whereas others differentiate to adapt to changed environmental conditions. The pleomorphic archaeon Haloferax volcanii commonly forms discoid-shaped ('plate') cells in culture, but may also be present as rods
Joseph E Kerschner et al.
Archives of otolaryngology--head & neck surgery, 135(1), 33-39 (2009-01-21)
To investigate genetic differences in middle ear mucosa (MEM) with nontypeable Haemophilus influenzae (NTHi) infection. Genetic upregulation and downregulation occurs in MEM during otitis media (OM) pathogenesis. A comprehensive assessment of these genetic differences using the techniques of complementary DNA
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