Pular para o conteúdo
Merck
Todas as fotos(3)

Key Documents

Outros documentos

T122

Sigma-Aldrich

Telenzepine dihydrochloride hydrate

solid, ≥98% (HPLC)

Sinônimo(s):

4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(3)

About This Item

Fórmula empírica (Notação de Hill):
C19H22N4O2S · 2HCl · xH2O
Número CAS:
147416-96-4
Peso molecular:
443.39 (anhydrous basis)
Número MDL:
MFCD11045947
Código UNSPSC:
12352200
ID de substância PubChem:
24277875
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

H2O: >10 mg/mL

cadeia de caracteres SMILES

O.Cl.Cl.CN1CCN(CC1)CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24

InChI

1S/C19H22N4O2S.2ClH.H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;1H2

chave InChI

HZWCRPGARSMPNS-UHFFFAOYSA-N

Informações sobre genes

human ... CHRM1(1128)

Aplicação

Telenzepine dihydrochloride hydrate was used to study M1 muscarinic receptor-mediated signaling in juvenile rat hippocampus and rat urinary bladder.

Ações bioquímicas/fisiológicas

Telenzepine is an analog of pirenzepine and inhibits the secretion of gastric acid. It is an antagonist to M1-receptor and targets the oxyntic gastric glands and the salivary glands.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 1

1 of 1

Adenosina 5′-trifosfato ≥95%, bacterial

Sigma-Aldrich

A9187

Adenosina 5′-trifosfato

K Kawashima et al.
General pharmacology, 21(1), 17-21 (1990-01-01)
1. Effects of three muscarinic antagonists on electrically evoked ACh release and contractile response were investigated in longitudinal muscle strips of guinea-pig ileum suspended in an organ-bath and superfused with Krebs solution. ACh release was determined by a specific radioimmunoassay.
G Bertaccini et al.
Pharmacological research, 21(4), 339-352 (1989-07-01)
The control of gastric secretion may be obtained by means of several pharmacological compounds: histamine H2 receptor antagonists and anticholinergics are so far the most widely employed drugs in pharmacological experiments and in clinical practice. The H2 blockers are able
G Coruzzi et al.
Archives internationales de pharmacodynamie et de therapie, 302, 232-241 (1989-11-01)
The new M1-receptor antagonist telenzepine has been studied for its antisecretory effect in different in vitro and in vivo experimental models in comparison with pirenzepine. Telenzepine was found to be from 3 to 10 times more potent than pirenzepine in
Turgut Emrah Bozkurt et al.
Pharmacological research, 59(5), 300-305 (2009-05-07)
We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial bioassay system. Acetylcholine-induced relaxation of a precontracted anococcygeus muscle mounted within the bladder was considered as an evidence for
A M Rosati et al.
Brain research, 815(2), 185-191 (1999-01-08)
Binding studies were used to assess the changes in affinity and/or number of M1 muscarinic receptors in hippocampi from juvenile rats chronically deprived of NGF. NGF deprivation was obtained by implanting into right ventricle at postnatal day 2 (P2) hybrydoma
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica