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SRP8047

Sigma-Aldrich

Omentin human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Sinônimo(s):

ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1

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About This Item

Número CAS:
786735-12-4
Código UNSPSC:
12352200
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in CHO cells

etiqueta

FLAG® tagged

Ensaio

>95% (SDS-PAGE)

forma

lyophilized

peso molecular

~38 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

ligand binding assay: suitable

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white

nº de adesão UniProt

Q8WWA0

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... ITLN1(55600)

Descrição geral

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.

Aplicação

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.

Ações bioquímicas/fisiológicas

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).

forma física

Lyophilized from PBS.

Reconstituição

Reconstitute with 100 μL deionized water.

Outras notas

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG®-tag.

Informações legais

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Michael Sigal et al.
Nature cell biology, 21(7), 812-823 (2019-06-27)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an increase in proliferation of Wnt-responsive
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
Hatzios SK
Nature Chemical Biology, 12(4), 268-274 (2016)
Dan Li et al.
Oncotarget, 6(18), 16168-16182 (2015-05-13)
Recent evidence shows the emerging roles of intelectin 1 (ITLN1), a secretory lectin, in human cancers. Our previous studies have implicated the potential roles of ITLN1 in the aggressiveness of gastric cancer. Herein, we investigated the functions, downstream targets, and
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer.
Shen XD
Cytokine, 77, 50-55 (2016)
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Yang RZ
American Journal of Physiology. Endocrinology and Metabolism, 290(6), E1253-E1261 (2006)
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