SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• Sinônimo(s): ACRP30headless:A-proliferation-inducing ligand, ACRP30headless:APRIL, ACRP30headless:CD256, TNFSF10
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• fonte biológica: mouse
• recombinante: expressed in HEK 293 cells
• etiqueta: FLAG^® tagged
• Ensaio: >95% (SDS-PAGE)
• forma: lyophilized
• peso molecular: ~34 kDa by SDS-PAGE
• embalagem: pkg of 10 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• Impurezas: <0.02 EU/μg endotoxin, tested
• cor: white
• nº de adesão UniProt: Q9D777
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: mouse ... Tnfsf13(69583)

Descrição

Descrição geral

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

forma física

Lyophilized from PBS.

Reconstituição

Reconstitute with 100 μL deionized water.

Outras notas

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

Informações legais

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable