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Key Documents

SRP8039

Sigma-Aldrich

Irisin

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Sinônimo(s):

CD121a, Fibronectin type III domain-containing protein 5 (cleaved), Fibronectin type III repeat-containing protein 2 (cleaved)

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About This Item

Número CAS:
1465928-51-1
Código UNSPSC:
12352202
NACRES:
NA.32

recombinante

expressed in CHO cells

etiqueta

FLAG® tagged

Ensaio

>95% (SDS-PAGE)

forma

lyophilized

peso molecular

~26 kDa

embalagem

pkg of 10 μg

Impurezas

<0.1 EU/μg endotoxin, tested

nº de adesão UniProt

Q8NAU1

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... FNDC5(252995)

Descrição geral

Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.

Ações bioquímicas/fisiológicas

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

forma física

Lyophilized from PBS.

Reconstituição

Reconstitute with 100 μL deionized water.

Outras notas

Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.

Informações legais

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance.
Moreno-Navarrete JM, et al.
The Journal of Clinical Endocrinology and Metabolism, 98, E769-E778 (2013)
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Huh JY, et al.
Metabolism, Clinical and Experimental, 61, 1725-1725 (2012)
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)

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