SRP8001

Calreticulin human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• Sinônimo(s): CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• etiqueta: His tagged
• Ensaio: >90% (SDS-PAGE)
• forma: liquid
• peso molecular: ~55 kDa by SDS-PAGE
• embalagem: pkg of 10 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• técnica(s): calcium flux assay: suitable
• Impurezas: <1 EU/μg endotoxin, tested
• nº de adesão UniProt: P27797
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... CALR(811)

Descrição

Descrição geral

Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.

Aplicação

Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca²⁺ entry pathway.

Ações bioquímicas/fisiológicas

Calreticulin is involved in regulation of intracellular Ca²⁺ homoeostasis and ER Ca²⁺ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

forma física

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

Outras notas

Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable