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Documentos Principais

SRP3325

Sigma-Aldrich

Uterglobin Peptide

≥98% (HPLC), human recombinant, expressed in E. coli

Sinônimo(s):

Clara cell phospholipid-binding protein, Secretoglobin family 1A member 1, Urinary protein 1

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

Nome do produto

UTERGLOBULIN human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥98% (HPLC)
≥98% (SDS-PAGE)

Formulário

lyophilized

peso molecular

8.0 kDa

embalagem

pkg of 50 μg

Impurezas

endotoxin, tested

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... SCGB1A1(7356)

Descrição geral

Uteroglobin, also known as clara cell phospholipid-binding protein or CC10, is a member of the secretoglobin superfamily. It is secreted from nonciliated cells in the epithelial lining of bronchioles, also referred as Clara cells. Uteroglobin is encoded by the gene mapped to human chromosome 11q12.2 – 13.1. Recombinant Human Uteroglobin is an 8.0kDa homodimeric protein consisting of 142 amino acid residues.

Ações bioquímicas/fisiológicas

Uteroglobin functions as an immunomodulatory and anti-inflammatory protein. Uteroglobin might play a vital role in regulation of airway inflammation. Elevated level of uteroglobin has been observed in fallopian tubes of tubal ectopic pregnant women and in female patients with pelvic inflammatory disease. Uteroglobin level is reduced in serum of asthmatic patients with a long duration of the disease. Uteroglobin stimulates the growth of preimplantation blastocysts and it functions as a carrier and/or scavenger of progesterone, decreasing its toxicity to the early developing embryo. Uteroglobin has the capacity to prevent both chemotaxis and phagocytosis of monocytes and neutrophils.

forma física

Lyophilized from 1 x PBS

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma.
Shijubo N
Lung, 177(1), 45-52 (1999)
Anil B Mukherjee et al.
Endocrine reviews, 28(7), 707-725 (2007-10-06)
Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. However, the physiological function(s) of UG still remains elusive. Isolated from the uterus of rabbits
Current knowledge of the aetiology of human tubal ectopic pregnancy.
Shaw JL
Human Reproduction Update, 16(4), 432-444 (2010)
Uteroglobin: a novel cytokine?
Mukherjee AB
Cellular and Molecular Life Sciences, 55(5), 771-787 (1999)

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