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Key Documents

SRP0354

Sigma-Aldrich

Aurora Kinase A active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

Sinônimo(s):

ARK1, AURA, BTAK, STK6

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About This Item

Número CAS:
458560-40-2
Código UNSPSC:
12352204
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in baculovirus infected Sf9 cells

Ensaio

≥90% (SDS-PAGE)

forma

aqueous solution

peso molecular

50 kDa

embalagem

pkg of 10 μg

técnica(s)

activity assay: suitable
inhibition assay: suitable

nº de adesão NCBI

NM_003600

nº de adesão UniProt

O14965

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... AURKA(6790)

Descrição geral

AURA/AURKA (aurora kinase A) is mapped to human chromosome 20q13.2. It is also termed as STK15 (serine/threonine kinase 15). This gene codes for a protein of 403 amino acids with regulatory and catalytic domains. AURA is overexpressed in several malignancies like invasive carcinomas of ovary, head, neck and breast.
Human Aurora kinase A (GenBank Accession No. NM_003600), amino acids 2- 403 with N-terminal HIS6-tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Aplicação

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Ações bioquímicas/fisiológicas

AURA/AURKA (aurora kinase A) modulates cell cycle checkpoints and plays important roles in centrosome division, cytoskeleton and cytokinesis. It sustains the integrity of chromosomes after DNA damage. The catalytic domain of AURKA possesses a serine/threonine kinase activity.

Definição da unidade

One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 1 peptide substarte per minute at pH 7.4 and 30°C.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East
Golmohammadi R, et al.
Medicine, 96(37) (2017)
Mutsuko Ouchi et al.
The Journal of biological chemistry, 279(19), 19643-19648 (2004-03-03)
Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition of the cell cycle. Previous studies have shown that the BRCA1 breast cancer tumor suppressor also localizes to the centrosome and
Naoko Kunitoku et al.
Developmental cell, 5(6), 853-864 (2003-12-12)
The Aurora (Ipl1)-related kinases are universal regulators of mitosis. We now show that Aurora-A, in addition to Aurora-B, regulates kinetochore function in human cells. A two-hybrid screen identified the kinetochore component CENP-A as a protein that interacts with Aurora-A. Aurora-A
Sunyi Lee et al.
FEBS letters, 588(17), 2844-2850 (2014-07-06)
IK is known to inhibit the expression of major histocompatibility complex (MHC) class II antigen, but other cellular functions of IK remain to be uncovered. In this study, IK depletion caused misalignment of chromosomes through an increase in Aurora A

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