SML3892

CB-6644

≥98% (HPLC)

• Sinônimo(s): CB6644, 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide, CB 6644
• Fórmula empírica (Notação de Hill): C₂₉H₃₄ClFN₄O₅
• Número CAS: 2316817-88-4
• Peso molecular: 573.06
• Número MDL: MFCD32689451
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C

Descrição

Ações bioquímicas/fisiológicas

CB-6644 is an orally active, non-ATP-competitive, potent and selective allosteric inhibitor against the RUVBL1/2 complex ATPase activity (IC50 = 15 nM; IC50 >100 μM against a panel of related AAA ATPases) with cancer killing potency in cultures (IC50 = 41-785 nM) and in xenograft myeloma models in vivo (150 mg/kg qd. or bid. via p.o.).

Orally active, potent and selective allosteric inhibitor against the RUVBL1/2 complex ATPase activity with cancer killing potency in cultures and in vivo.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable