SML3817

TLR2-IN-C29

≥98% (HPLC)

• Sinônimo(s): 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methylbenzoic acid, C29
• Fórmula empírica (Notação de Hill): C₁₆H₁₅NO₄
• Número CAS: 363600-92-4
• Peso molecular: 285.29
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: yellow to orange
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: -10 to -25°C
• cadeia de caracteres SMILES: O=C(C1=C(C)C(N=CC2=C(O)C(OC)=CC=C2)=CC=C1)O

Descrição

Ações bioquímicas/fisiológicas

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist that inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable