SML3625

BAY-069

≥98% (HPLC)

• Sinônimo(s): 3-(4-Chloro-3-(o-tolyloxy)naphthalen-1-yl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, 3-(5-chloro-4-(2-methyl-phenoxy)-bicyclo[4.4.0]deca-1(6),2,4,7,9-pentaen-2-yl)-6-(trifluoro-methyl)-1,2,3,4-tetrahydro-pyrimidine-2,4-dione, BAY 069, BAY069
• Fórmula empírica (Notação de Hill): C₂₂H₁₄ClF₃N₂O₃
• Número CAS: 2639638-67-6
• Peso molecular: 446.81
• Número MDL: MFCD34789523
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• Condições de expedição: wet ice
• temperatura de armazenamento: −70°C

Descrição

Ações bioquímicas/fisiológicas

BAY-069 is a non-cytotoxic (anti-proliferation IC50 >47 μM using 6 cell lines), potent and selective branched chain amino acid (BCAA) transaminase (BCAT) inhibitor (BCAT1/2 IC50 = 27/130 nM; glutamic-oxaloacetic transaminase GOT1/2 IC50 >50 μM) with good selectivity over a panel of 30 kinases, 30 proteases and 77 other targets. BAY-069 upregulates BCAAs in high BCAT1-expressing U-87 MG and high BCAT2-expressing MDA-MB-231 (IC50 = 358 and 874 nM, respectively) with good pharmacokinetics and oral bioavailability in rats in vivo.

Orally available, non-cytotoxic, potent and selective branched chain amino acid (BCAA) transaminase 1/2 (BCAT1 & BCAT2) inhibitor.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable