SML3312

SRI-41315

≥95% (HPLC)

• Sinônimo(s): 2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
• Fórmula empírica (Notação de Hill): C₂₂H₁₉N₃O₂
• Número CAS: 1613509-49-1
• Peso molecular: 357.41
• Código UNSPSC: 51111800
• NACRES: NA.32

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear (Warmed)
• temperatura de armazenamento: -10 to -25°C
• cadeia de caracteres SMILES: O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O

Descrição

Ações bioquímicas/fisiológicas

Cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon

SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable