Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

View All Documentation

SML3102

Sigma-Aldrich

Ceftaroline fosamil acetate hydrate

≥98% (HPLC)

Sinônimo(s):

4-(2-((6R,7R)-2-Carboxy-7-((Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-ylthio)thiazol-4-yl)-1-methylpyridinium acetate, hydrate, Ceftaroline fosamil acetate hydrate, PPI 0903 hydrate, PPI-0903 hydrate, PPI0903 hydrate, TAK 599 hydrate, TAK-599 hydrate, TAK599 hydrate

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C22H22N8O8PS4 · C2H3O2 · xH2O
Número CAS:
400827-46-5
Peso molecular:
744.74 (anhydrous basis)
Número MDL:
MFCD29920090
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear (warmed)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[N+]1=CC=C(C=C1)C2=CSC(SC(CS[C@@]3([C@@H]4NC(/C(C5=NSC(NP(O)(O)=O)=N5)=N\OCC)=O)[H])=C(N3C4=O)C(O)=O)=N2.CC([O-])=O

Ações bioquímicas/fisiológicas

Ceftaroline fosamil (PPI-0903, TAK-599) is a N-phosphono type prodrug of ceftaroline (cephalosporin 2a, PPI-0903M, T-91825), a fifth-generation penicillin-binding protein (PBP)-targeting cephalosporin class beta-lactam (β-lactam) antibiotic with broad-spectrum activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and extensively-resistant strains, such as vancomycin-intermediate S. aureus (VISA), heteroresistant VISA (hVISA), and vancomycin-resistant S. aureus (VRSA).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

D Andes et al.
Antimicrobial agents and chemotherapy, 50(4), 1376-1383 (2006-03-30)
PPI-0903 is a new cephalosporin with broad-spectrum activity, including beta-lactam-resistant Streptococcus pneumoniae and Staphylococcus aureus. We used the neutropenic murine thigh and lung infection models to examine the pharmacodynamic characteristics of PPI-0903. Serum drug levels following four fourfold-escalating single doses
Evaluation of the in vivo efficacy of intramuscularly administered ceftaroline fosamil, a novel cephalosporin, against a methicillin-resistant Staphylococcus aureus strain in a rabbit endocarditis model.
Cédric Jacqueline et al.
The Journal of antimicrobial chemotherapy, 65(10), 2264-2265 (2010-08-19)
Christopher Duplessis et al.
Clinical medicine reviews in therapeutics, 3 (2011-07-26)
Microbial resistance has reached alarming levels, threatening to outpace the ability to counter with more potent antimicrobial agents. In particular, methicillin-resistant Staphylococcus aureus (MRSA) has become a leading cause of skin and soft-tissue infections and PVL-positive strains have been associated
Cédric Jacqueline et al.
Antimicrobial agents and chemotherapy, 51(9), 3397-3400 (2007-06-27)
Using the rabbit endocarditis model, we compared the activity of a new broad-spectrum cephalosporin, ceftaroline, with those of linezolid and vancomycin against methicillin-resistant Staphylococcus aureus. After a 4-day treatment, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica