SML3005

NMDAR/TRPM4 interface inhibitor C19 dihydrochloride

≥98% (HPLC)

• Sinônimo(s): 2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride, C19 dihydrochloride, Compound 19 dihydrochloride, N-(2,4,5-Trichlorophenyl)-3-aminomethyl-1-pyrrolidineacetamide dihydrochloride
• Fórmula empírica (Notação de Hill): C₁₃H₁₆Cl₃N₃O·2HCl
• Número CAS: 2241128-93-6
• Peso molecular: 409.57
• Número MDL: MFCD31666003
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: H₂O: 2 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(CN1CC(CC1)CN)NC2=CC(Cl)=C(C=C2Cl)Cl.Cl.Cl

Descrição

Ações bioquímicas/fisiológicas

Compound 19 (C19) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C19 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 1.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable