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Merck
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Key Documents

SML2566

Sigma-Aldrich

CL097

≥98% (HPLC)

Sinônimo(s):

2-(Ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine, CL 097, CL-097

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About This Item

Fórmula empírica (Notação de Hill):
C13H14N4O
Número CAS:
Peso molecular:
242.28
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

cor

white to very dark brown

solubilidade

DMSO: 2 mg/mL, clear (warmed)

temperatura de armazenamento

2-8°C

Ações bioquímicas/fisiológicas

CL097 is an imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. CL097 is commonly employed in the concentration range from 0.5 μg/mL to 45 μg/mL for stimulating cell surface TLR7/8 in cultures and is reported to be a stronger TLR7 ligand than CL075.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Rebecca H Johnson et al.
Scientific reports, 8(1), 10102-10102 (2018-07-06)
Toll-Like receptors (TLRs) represent an important early warning mechanism for the immune system to detect infection or tissue damage. The focus of this research was to determine the neuroinflammatory responses to commercial TLR ligands and their effects on brain endothelial
Emily Pfeifer et al.
Placenta, 69, 32-39 (2018-09-15)
The objectives of this study were to determine how HCV infection affects placental drug transporters, and to determine the role of drug transporters on the cellular accumulation of direct-acting antiviral drugs in human trophoblasts. Eighty-four ABC and SLC transporter genes
Masaaki Okamoto et al.
The Journal of biological chemistry, 293(48), 18585-18600 (2018-10-05)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the blood and can deliver functional RNAs, such as microRNAs (miRNAs), to
A León-Flores et al.
Immunology letters, 203, 70-79 (2018-09-22)
Recent evidence has revealed that PD-L1 is expressed in two functional forms, namely, a membrane-bound form (mPD-L1) and a soluble form (sPD-L1). The identification of the soluble form of PD-L1 represents the discovery of a new potential mechanism for the
Xinqiang Hong et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 30(2), 197-208 (2018-06-05)
The aim of the present study was to investigate the effects of 5-fluorouracil (5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells (DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide (α-GC) tumor vaccine exhibits

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