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Key Documents

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SML2377

Sigma-Aldrich

GSK′962

≥98% (HPLC)

Sinônimo(s):

1-[(5R)-4,5-Dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-1-propanone; 2,2-Dimethyl-1-(5(R)-phenyl-4,5-dihydro-pyrazol-1-yl)-propan-1-one, GSK 962, GSK 963 inactive control, GSK 963 negative control, GSK′ 962A, GSK′962A, GSK′963 inactive control, GSK′963 negative control, GSK-962, GSK-962A, GSK962, GSK962A

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About This Item

Fórmula empírica (Notação de Hill):
C14H18N2O
Número CAS:
2049872-86-6
Peso molecular:
230.31
Código UNSPSC:
12352200

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C(C(C)(C)C)N1[C@@H](C2=CC=CC=C2)CC=N1

Ações bioquímicas/fisiológicas

GSK′962 (GSK′962A) corresponds to the inactive (R)-enantiomer of the highly potent and selective RIPK1 (RIP1) inhibitor GSK′963 (GSK′963A). GSK′962 serves as an ideal GSK′963 negative control compound for probing RIPK1-mediated responses both in vitro and in vivo.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Nivea Farias Luz et al.
Journal of immunology (Baltimore, Md. : 1950), 196(12), 5056-5063 (2016-05-18)
Leishmaniasis is an important parasitic disease found in the tropics and subtropics. Cutaneous and visceral leishmaniasis affect an estimated 1.5 million people worldwide. Despite its human health relevance, relatively little is known about the cell death pathways that control Leishmania
Mallary C Greenlee-Wacker et al.
Blood, 129(24), 3237-3244 (2017-05-06)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causes infections associated with extensive tissue damage and necrosis. In vitro, human neutrophils fed CA-MRSA lyse by an unknown mechanism that is inhibited by necrostatin-1, an allosteric inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK-1). RIPK-1
Wenjing Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(7), E1475-E1484 (2018-02-01)
Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is a type of programed necrosis, which is executed by mixed lineage kinase domain-like protein (MLKL) upon its binding to the plasma membrane. Emerging evidence indicates
S B Berger et al.
Cell death discovery, 1, 15009-15009 (2015-01-01)
Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the
Dan Weng et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7391-7396 (2014-05-07)
A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous for its role in large pandemics such as the "Black Death" in medieval Europe, induces considerable cytotoxicity. The rapid killing of macrophages induced by Y. pestis

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