SML0919

ML221

≥98% (HPLC)

• Sinônimo(s): 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• Fórmula empírica (Notação de Hill): C₁₇H₁₁N₃O₆S
• Número CAS: 877636-42-5
• Peso molecular: 385.35
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 5 mg/mL, clear (warmed)
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2
• chave InChI: UASIRTUMPRQVFY-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC₅₀ of 1.75 μM.

ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts.

Características e benefícios

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Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable