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SML0542

Sigma-Aldrich

SR 27417

≥98% (HPLC)

Sinônimo(s):

Faropafant, N,N-Dimethyl-N′-(3-pyridinylmethyl)-N′-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine, N1,N1-Dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine

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About This Item

Fórmula empírica (Notação de Hill):
C28H40N4S
Número CAS:
136468-36-5
Peso molecular:
464.71
Número MDL:
MFCD00904759
Código UNSPSC:
12352200
ID de substância PubChem:
329825543
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL (clear solution, warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc3cccnc3)c(c1)C(C)C

InChI

1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3

chave InChI

VVBFISAUNSXQGZ-UHFFFAOYSA-N

Categorias relacionadas

Ações bioquímicas/fisiológicas

SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist.
SR 27417 is a selective, highly potent, competitive platelet-activating factor (PAF) receptor antagonist.

Características e benefícios

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
112M4603V

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H C Castro-Faria-Neto et al.
Planta medica, 61(2), 106-112 (1995-04-01)
The pharmacological profile of a novel specific platelet-activating factor (PAF) receptor antagonist-yangambin-isolated from the Brazilian plant Ocotea duckei Vattimo (Lauraceae), was investigated in the pentobarbitone-anaesthetized rabbit. The i.v. administration of PAF (0.03-3.0 microgram kg-1) induced marked but reversible hypotensive effects
S O Heard et al.
Journal of critical care, 10(1), 7-14 (1995-03-01)
To determine if platelet-activating factor (PAF) is a key mediator of lipopolysaccharide (LPS)-induced myocardial depression in guinea pigs. Hartley guinea pigs of either sex received intraperitoneal (IP) injections of either vehicle (n = 45) or one of three chemically dissimilar
M Fonteles et al.
Journal of lipid mediators and cell signalling, 11(2), 133-143 (1995-03-01)
Clostridium difficile is a major recognized cause of antibiotic-associated diarrhea, an effect mediated through its toxin A. Toxin A has been reported to disrupt epithelial tight junctions, attract neutrophils, and cause striking intestinal inflammation and secretion. Having demonstrated that phospholipase
J M Herbert et al.
Journal of lipid mediators and cell signalling, 12(1), 49-57 (1995-07-01)
In order to evaluate the relative importance platelet-activating factor (PAF) in the proliferative process leading to restenosis, the effect of SR 27417, a novel highly potent PAF receptor antagonist, on PAF-induced rabbit aortic smooth muscle cell (SMC) proliferation and intimal
R L Guerrant et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(20), 9655-9658 (1994-09-27)
With the recent heightened concern about cholera around the world come new questions about the mechanism by which cholera toxin causes diarrhea. Peterson and Ochoa have suggested that prostaglandin synthesis is key to both the intestinal epithelial secretory and the
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