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SML0453

Sigma-Aldrich

TBPB

≥98% (HPLC)

Sinônimo(s):

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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About This Item

Fórmula empírica (Notação de Hill):
C25H32N4O
Número CAS:
634616-95-8
Peso molecular:
404.55
Número MDL:
MFCD22666590
Código UNSPSC:
12352200
ID de substância PubChem:
329824732
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL (clear solution; warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45

InChI

1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)

chave InChI

CWPKTBMRVATCBL-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist.
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
082M4626V

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Hidenori Hashimoto et al.
Scientific reports, 7(1), 17216-17216 (2017-12-10)
Ionic clathrate hydrates can selectively capture small gas molecules such as CO
Ashwini Kumar et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 115(1), 3-10 (2015-07-30)
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, i.e., dementia. The disease starts with mild symptoms and gradually becomes severe. AD is one of the leading causes of
Shang-Chi Lin et al.
Scientific reports, 4, 6976-6976 (2014-11-14)
A good diagnostic procedure avoids wasting medical resources, is easy to use, resists contamination, and provides accurate information quickly to allow for rapid follow-up therapies. We developed a novel diagnostic procedure using a "cotton-based diagnostic device" capable of real-time detection
Ya'nan Wang et al.
Polymers, 12(5) (2020-05-30)
Ring-opening copolymerization (ROCOP) is an effective means to prepare functionalized polyester. In this work, a type of selenide-containing polyesters with controllable structure, molecular weight, and molecular weight distribution was successfully prepared by ROCOP of γ-selenobutyrolactone and epoxy compounds. The influence

Artigos

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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